Creating a microcircuit of the striatum using connectivity, morphological and electrophysiological data

Alexander Kozlov

doi:10.1117/12.2594713

1 August 2021 Creating a microcircuit of the striatum using connectivity, morphological and electrophysiological data

Alexander Kozlov

Proceedings Volume 11804, Emerging Topics in Artificial Intelligence (ETAI) 2021; 118040N (2021) https://doi.org/10.1117/12.2594713
Event: SPIE Nanoscience + Engineering, 2021, San Diego, California, United States

Abstract

Availability of the high-performance computing resources makes possible simulations of the neural networks at unprecedented resolution and high biological realism. Creating a microcircuit of the dorsal striatum is discussed on the example of the mouse brain. Models of striatal projection neurons and interneurons are built using multi-objective optimization procedure. Special attention is paid to ensure variability of morpho-electric features within the simulated population of the nerve cells. Synaptic connectivity within the reconstructed microcircuit is anatomically constrained by the morphology of individual cells and further tuned to match the experimentally observed connection probability for all known local projections. Reconstructed microcircuit faithfully reproduces background activity of the striatum as well as the typical response to the external stimulation and can be used to study the striatal dynamics in healthy and diseased states.

Conference Presentation

Citation Download Citation

Alexander Kozlov "Creating a microcircuit of the striatum using connectivity, morphological and electrophysiological data", Proc. SPIE 11804, Emerging Topics in Artificial Intelligence (ETAI) 2021, 118040N (1 August 2021); https://doi.org/10.1117/12.2594713

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