Objective: to study the dynamics of the state of autografts of skin and allodermal protectors on a wound using multimodal optical monitoring. Material and methods. A burn wound was simulated in rats (n = 16), 20% of the wound area was covered with skin autografts. The allodermal protector of 0.35 mm thick was applied over the autografts. Studied in vivo the state of the grafts for 10 days: saturation - according to diffuse optical spectroscopy (DOS); perfusion - according to laser Doppler flowmetry (LDF); microstructure - according to optical coherence tomography (OCT). Results. Multimodal monitoring of blood circulation, metabolism and microstructure of skin grafts on a burn wound showed that changes in auto- and allografts occur asynchronously. In the tissues of the autograft, blood saturation directly correlated with the restoration of perfusion (Spearman's coefficient = 0.795); in the allograft, the correlation between perfusion and saturation was weakly inverse (-0.179). Those differences were confirmed by OCT data and histological analysis: allografts lost their normal microstructure simultaneously with a rapid decrease of the blood saturation, despite the preservation of perfusion parameters.
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