A survey of imaging mass spectrometry methods in the pharmaceutical industry: initial steps to establishing best practices for use in a regulated environment

E. G. Solon

doi:10.1117/12.2610677

3 March 2022 A survey of imaging mass spectrometry methods in the pharmaceutical industry: initial steps to establishing best practices for use in a regulated environment

E. G. Solon

Author Affiliations +

Proceedings Volume 11938, Visualizing and Quantifying Drug Distribution in Tissue VI; 1193802 (2022) https://doi.org/10.1117/12.2610677
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Imaging mass spectrometry (IMS) has emerged as a powerful technology in the pharmaceutical industry with many applications to enhance drug discovery and development. In order to use IMS to support drug development, IMS researchers must develop, validate, and establish best practices to assure data integrity to adequately support new drug registrations. The Imaging Mass Spectrometry Society (IMSS) initiated a project to examine how MS is currently being used in the industry and partnered with the Japan Association for Imaging Mass Spectrometry (JAIMS) to conduct a thorough survey of IMS scientists, data analysts/users, project managers/leaders, and pharmaceutical compliance specialists who currently use IMS techniques in support of their drug discovery and development efforts. The survey asked detailed questions related to technical aspects of: 1. sample collection & preparation; 2. qualitative and quantitative sample analysis; 3. examination of parent drug, metabolites and biomarkers; 4. data acquisition, reporting and integrity; 5. General applications; and 6. regulatory concerns. This international survey was conducted online through Survey Monkey in both English and Japanese in September of 2020, with a goal of beginning efforts to establish best practices for the wide acceptance of IMS data for use in regulated drug development industry. This oral presentation will discuss the preparation and conduct of the survey, survey results, and to provide the audience with an approach to developing surveys to help establish best practices for the application of other drugimaging technologies in the Pharmaceutical Industry.

Conference Presentation

Citation Download Citation

E. G. Solon "A survey of imaging mass spectrometry methods in the pharmaceutical industry: initial steps to establishing best practices for use in a regulated environment", Proc. SPIE 11938, Visualizing and Quantifying Drug Distribution in Tissue VI, 1193802 (3 March 2022); https://doi.org/10.1117/12.2610677

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available