Preferential uptake of glucose-functionalized liposomes by cancer cells

Chen Tzror-Azankot; Tamar Sadan; Ayelet Atkins; Menachem Motiei; Rachela Popovtzer

doi:10.1117/12.2608826

3 March 2022 Preferential uptake of glucose-functionalized liposomes by cancer cells

Chen Tzror-Azankot, Tamar Sadan, Ayelet Atkins, Menachem Motiei, Rachela Popovtzer

Proceedings Volume 11976, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIX; 119760B (2022) https://doi.org/10.1117/12.2608826
Event: SPIE BiOS, 2022, San Francisco, California, United States

Conference Poster

Abstract

Liposomes are a promising drug delivery system, owing to their biocompatibility and ability to efficiently encapsulate and protect a wide range of molecules for medical applications. Active targeting of the liposomes is typically performed by surface modification, which enables delivery of the liposomes to a specific target tissue. Tumor cells are characterized by high glucose demand and high metabolic activity, because of the increased requirement of energy to feed uncontrolled proliferation. Taking advantage of the increased glucose uptake by cancer cells, we developed a glucose-labeled liposome, which is tumor-targeted - both by recognition of over-expressed glucose transporters on tumor cells, and by the unique characteristics of tumor vasculature that allow greater accumulation of nanoparticles. In this study, glucosecoated liposome uptake was evaluated in different types of cancer cells, both quantitatively and qualitatively. We found that liposomes with glucose coating were preferentially uptaken by cancer cell lines with high metabolic activity, compared to liposomes without glucose coating. Moreover, cell lines with high metabolic activity exhibited higher uptake of liposomes with glucose coating, as compared to cell lines with low metabolic activity and to non-cancerous cell lines.

Citation Download Citation

Chen Tzror-Azankot, Tamar Sadan, Ayelet Atkins, Menachem Motiei, and Rachela Popovtzer "Preferential uptake of glucose-functionalized liposomes by cancer cells", Proc. SPIE 11976, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIX, 119760B (3 March 2022); https://doi.org/10.1117/12.2608826

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available