One- and two-photon crosslinked polymer hydrogel microstructures for optical spectroscopy and biosensing applications

Yevhenii M. Morozov; Nestor Gisbert Quilis; Fiona Diehl; Sven Klees; Jonas J. Grün; Ulrich Jonas; Jakub Dostalek

doi:10.1117/12.2621516

31 May 2022 One- and two-photon crosslinked polymer hydrogel microstructures for optical spectroscopy and biosensing applications

Yevhenii M. Morozov, Nestor Gisbert Quilis , Fiona Diehl, Sven Klees, Jonas J. Grün, Ulrich Jonas, Jakub Dostalek

Author Affiliations +

Proceedings Volume 12145, Biophotonics in Point-of-Care II; 1214502 (2022) https://doi.org/10.1117/12.2621516
Event: SPIE Photonics Europe, 2022, Strasbourg, France

Abstract

In this work, we report on a polymer toolkit for fabrication of hydrogel microstructures by means of one- and two-photon crosslinking process. Using home-built and commercial multi-photon lithography setups, we show the ability to prepare hydrogel structures attached to a solid substrate from developed copolymer or terpolymer layers. These polymers bear a photo-active benzophenone or anthraquinone moieties and additional groups enabling their chemical post-modification with biofunctional molecules. The crosslinked polymer networks can swell in water forming hydrogel structures with a geometry controlled by the UV or two-photon crosslinking imposed by a focused beam scanned over the substrate. In conjunction with post-modification, these micro-structured materials may serve in biosensing and other emerging applications such as responsive hydrogel-based miniature actuators supporting microfluidic devices and micromachines.

Conference Presentation

Citation Download Citation

Yevhenii M. Morozov, Nestor Gisbert Quilis , Fiona Diehl, Sven Klees, Jonas J. Grün, Ulrich Jonas, and Jakub Dostalek "One- and two-photon crosslinked polymer hydrogel microstructures for optical spectroscopy and biosensing applications", Proc. SPIE 12145, Biophotonics in Point-of-Care II, 1214502 (31 May 2022); https://doi.org/10.1117/12.2621516

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