Enhancing speckle statistics for imaging inside scattering tissue

Wei-Yu Chen; Matthew O'Toole; Aswin C. Sankaranarayanan; Anat Levin

doi:10.1117/12.2648905

16 March 2023 Enhancing speckle statistics for imaging inside scattering tissue

Wei-Yu Chen, Matthew O'Toole, Aswin C. Sankaranarayanan, Anat Levin

Proceedings Volume 12388, Adaptive Optics and Wavefront Control for Biological Systems IX; 1238809 (2023) https://doi.org/10.1117/12.2648905
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We exploit memory effect correlations in speckles for the imaging of incoherent fluorescent sources behind scattering tissue. These correlations are often weak when imaging thick scattering tissues and complex illumination patterns, both of which greatly limit the practicality of associated techniques. In this work, we introduce a spatial light modulator between the tissue sample and the imaging sensor and capture multiple modulations of the speckle pattern. We show that, by correctly designing the modulation patterns and the associated reconstruction algorithm, the statistical correlations in the measurements can be greatly enhanced. We exploit this to demonstrate the reconstruction of mega-pixel sized fluorescent patterns behind the scattering tissue.

Conference Presentation

Citation Download Citation

Wei-Yu Chen, Matthew O'Toole, Aswin C. Sankaranarayanan, and Anat Levin "Enhancing speckle statistics for imaging inside scattering tissue", Proc. SPIE 12388, Adaptive Optics and Wavefront Control for Biological Systems IX, 1238809 (16 March 2023); https://doi.org/10.1117/12.2648905

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