The correlation between mutated genes and leiomyosarcoma primary sites

Kangqi Li; Shuyan Qiu

doi:10.1117/12.2669579

24 March 2023 The correlation between mutated genes and leiomyosarcoma primary sites

Kangqi Li, Shuyan Qiu

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 1261127 (2023) https://doi.org/10.1117/12.2669579
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

Purpose: Leiomyosarcoma (LMS) is a type of soft tissue cancer, and the most common three primary sites are the connective and other soft tissues, the uterus, or the retroperitoneum and peritoneum. Previous studies focused on the genetic differences of LMS at different primary sites, but they did not compare the differ-ence between the primary sites. Methods and results: We obtained 85 cases of da-ta from the TCGA project. In the ridge model, the mutations at AP000769, DNAH5, FCGBP, DNAH7, OR10Z1, and LRRIQ3 show statistically significant (p<0.1) in resulting in LMS at the different primary sites. Among them, AP000769, DNAH5, FCGBP, and DNAH7 have a stronger association with p<0.05. Conclusions: We found a significant association between the primary sites of LMS and six specific genes, based on a statistical analysis of the GDC data portal. these results require molecular and cellular study to confirm the roles of noted genes.

Citation Download Citation

Kangqi Li and Shuyan Qiu "The correlation between mutated genes and leiomyosarcoma primary sites", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 1261127 (24 March 2023); https://doi.org/10.1117/12.2669579

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