Lactate: the underestimated metabolite and its important roles in cell regulation

Qinhui Huang

doi:10.1117/12.2669945

24 March 2023 Lactate: the underestimated metabolite and its important roles in cell regulation

Qinhui Huang

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 1261140 (2023) https://doi.org/10.1117/12.2669945
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

Lactate, one of the intermediates of metabolic pathways, is becoming the object of researches in recent years. It is found that it is not the waste product from anaerobic respiration, instead, it is considered an important effector for cancer development, cell homeostasis and energy storage for nerve cells in the absent of glucose. Also, it acts as a key signaling molecules not only in cellular metabolic fluxes, but also in immune cell polarization, helping tumor cells escape from immune surveillance. Hence, in depth study of lactate would achieve early diagnosis and treatment of diseases. This paper will focus on the newly understanding of lactate and its stimulation of histone lysine lactylation in the post-translational modification.

Citation Download Citation

Qinhui Huang "Lactate: the underestimated metabolite and its important roles in cell regulation", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 1261140 (24 March 2023); https://doi.org/10.1117/12.2669945

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available