The quantitative genetic study on the Alzheimer’s disease

Chuanjia Ju

doi:10.1117/12.2669388

24 March 2023 The quantitative genetic study on the Alzheimer’s disease

Chuanjia Ju

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 1261154 (2023) https://doi.org/10.1117/12.2669388
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

The Alzheimer’s disease is a neurodegenerative disorder and the most prevalent dementia. In 2022, over 10% of more than 65-year-old individuals are suffered from the Alzheimer’s disease in USA. This disorder is multifactorial and genetic factors are crucial for the development of the Alzheimer’s disease. To determine specific genetic factors and estimate the relative influence of genetic factors on the Alzheimer’s Disease, quantitative genetic studies including twin studies and family studies are utilised by researchers. However, quantitative genetic studies could be limited by not being representative and insufficient sample size. To strengthen the conclusion obtained from quantitative studies, molecular genetic studies such as GWAS metanalysis could be applied to provide possible development pathways of different genetic factors. The combination of these studies for research on the Alzheimer’s disease could also aid investigations of other disorders and behaviours, providing more evidence based basis for the diagnosis and treatment of the disease.

Citation Download Citation

Chuanjia Ju "The quantitative genetic study on the Alzheimer’s disease", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 1261154 (24 March 2023); https://doi.org/10.1117/12.2669388

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