Laser speckle contrast imaging of cerebral blood flow during carotid artery clamping

Dmitry Stavtsev; Igor Kozlov; Anton Konovalov; Fyodor Grebenev; Gennadii Piavchenko; Alexander Gerasimenko; Dmitry Telyshev; Igor Meglinski; Sergey Kuznetsov

doi:10.1117/12.2670756

8 December 2023 Laser speckle contrast imaging of cerebral blood flow during carotid artery clamping

Dmitry Stavtsev, Igor Kozlov, Anton Konovalov, Fyodor Grebenev, Gennadii Piavchenko, Alexander Gerasimenko, Dmitry Telyshev, Igor Meglinski, Sergey Kuznetsov

Author Affiliations +

Proceedings Volume 12628, Diffuse Optical Spectroscopy and Imaging IX; 126281S (2023) https://doi.org/10.1117/12.2670756
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

In neurosurgical operations, such as cerebral aneurysm clipping, bypass surgery and arteriovenous malformations, monitoring of cerebral blood flow is critically important. Currently, surgeons do not have real-time noninvasive methods for intraoperative visualization of cerebral blood flow. Laser speckle contrast imaging (LSCI), widely used in the diagnosis of blood flow, may be promising for solving this problem. In the present study, the LSCI was demonstrated for the evaluation of acute cerebral blood flow abnormalities in laboratory animals. To visualize cerebral blood flow, the rats underwent cranial trepanation. The disruption of cerebral blood circulation was simulated by clamping both common carotid arteries through the neck approach. A specially designed LSCI system was used to assess blood flow. A distinct reduction in blood flow in the cerebral cortex after carotid artery clipping was shown, which lasted for 10 min continuously. At the same time, a more intensive blood flow decrease was observed in the right hemisphere, which can be related to the blood supply of the left hemisphere through the circle of Willis. After the clips were removed, blood flow in both hemispheres was restored to a level higher than the initial level. The results obtained show the prospects of using LSCI for the control of acute disorders of cerebral blood flow during neurosurgical operations in real-time.

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Dmitry Stavtsev, Igor Kozlov, Anton Konovalov, Fyodor Grebenev, Gennadii Piavchenko, Alexander Gerasimenko, Dmitry Telyshev, Igor Meglinski, and Sergey Kuznetsov "Laser speckle contrast imaging of cerebral blood flow during carotid artery clamping", Proc. SPIE 12628, Diffuse Optical Spectroscopy and Imaging IX, 126281S (8 December 2023); https://doi.org/10.1117/12.2670756

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KEYWORDS

Cerebral blood flow

Laser speckle contrast imaging

Arteries

Blood circulation

Surgery

Visualization

Brain diseases

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