Myocardium tissue alterations in acute cardiac attack and respiratory arrest evaluated by polarized light

E. A. Kuzmin; A. S. Balkivskiy; T. G. Koryashkina; N. L. Kartashkina; A. N. Yatskovskiy; I. Meglinski; G. A. Piavchenko

doi:10.1117/12.2671005

11 August 2023 Myocardium tissue alterations in acute cardiac attack and respiratory arrest evaluated by polarized light

E. A. Kuzmin, A. S. Balkivskiy, T. G. Koryashkina, N. L. Kartashkina, A. N. Yatskovskiy, I. Meglinski, G. A. Piavchenko

Author Affiliations +

Proceedings Volume 12629, Emerging Technologies for Cell and Tissue Characterization II; 1262907 (2023) https://doi.org/10.1117/12.2671005
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

Many pathologies leading to the death of the organism are tied to the cessation of cardiac or respiratory activity. In the present study, we studied the microscopic structure of the myocardium of male Wistar rats under conditions of acute cardiac and respiratory arrest. Unstained histological sections of the myocardium are examined with a polarizing microscope for the length of the sarcomere, A- and I-discs measurements. The results of the study showed that the length of the sarcomere during respiratory arrest and cardiac attack significantly decreases due to the length of the I-disc, especially in acute cardiac attack. Correlation-regression analysis showed sharp decrease of correlation in acute respiratory arrest, reaching extremely low values in cardiac attack. The study allows assessing ultrastructural changes in the myocardium and forms the basis for diagnosing acute heart pathology with the machine learning and automated analysis.

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E. A. Kuzmin, A. S. Balkivskiy, T. G. Koryashkina, N. L. Kartashkina, A. N. Yatskovskiy, I. Meglinski, and G. A. Piavchenko "Myocardium tissue alterations in acute cardiac attack and respiratory arrest evaluated by polarized light", Proc. SPIE 12629, Emerging Technologies for Cell and Tissue Characterization II, 1262907 (11 August 2023); https://doi.org/10.1117/12.2671005

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