CRISPR-Cas system: revolutionizing plant breeding and gene therapy

Tianyi Song; Jingwen Wang; Yinxuan Wu

doi:10.1117/12.2692353

7 September 2023 CRISPR-Cas system: revolutionizing plant breeding and gene therapy

Tianyi Song, Jingwen Wang, Yinxuan Wu

Proceedings Volume 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023); 127890V (2023) https://doi.org/10.1117/12.2692353
Event: International Conference on Modern Medicine and Global Health (ICMMGH 2023), 2023, Oxford, United Kingdom

Abstract

Gene editing refers to the deletion, replacement, and insertion of target genes to obtain new functions. Nowadays, ZFN, TALEN and CRISPR-Cas are known as the three major technologies of gene editing which are used widely on more and more occasions. The common points of these three editing tools are that the recognition region contains the target DNA sequence and the DNA cleavage functional region. As a revolutionary tool in the field of life sciences, CRISPR-Cas and its derivative editing technologies may revolutionize biological research and affect personalized medicine in the future. Herein, the feature of CRISPR-Cas system and the process of discovery were summarized. Additionally, its principle mechanism was described in detail in this paper. Besides, CRISPR-Cas also played an important role in plant-related fields and gene therapy which were mentioned. However, there were problems in the application of technology, and the discussion started from the ethical controversy brought about by this technology. This review aims to deepen the understanding of gene editing technology, gain a deeper understanding of its functions, and provide theoretical support for subsequent research.

Citation Download Citation

Tianyi Song, Jingwen Wang, and Yinxuan Wu "CRISPR-Cas system: revolutionizing plant breeding and gene therapy", Proc. SPIE 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023), 127890V (7 September 2023); https://doi.org/10.1117/12.2692353

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KEYWORDS

Proteins

Animal model studies

Target recognition

Calcium

Genetics

Diseases and disorders

Animals

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