The profile of receptor protein tyrosine kinases (RPTKs): taking AXL and DDR as examples

Mingxin Gu; Yifan Lu; Yuxin Jin

doi:10.1117/12.2692473

7 September 2023 The profile of receptor protein tyrosine kinases (RPTKs): taking AXL and DDR as examples

Mingxin Gu, Yifan Lu, Yuxin Jin

Proceedings Volume 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023); 1278911 (2023) https://doi.org/10.1117/12.2692473
Event: International Conference on Modern Medicine and Global Health (ICMMGH 2023), 2023, Oxford, United Kingdom

Abstract

Receptor protein tyrosine kinases (RPTKs) comprise a unit of cell surface proteins that bind to ligands, which can phosphorylate tyrosine residues of the target protein. As RPTKs can make the receptor's tyrosine be transphosphorylated to transmit signals through the plasma membrane, it has been verified to be a key regulator of normal cellular processes and plays a key role in the development and progression of many types of cancer. Moreover, there are already much medicine under research based on RPTKs and their targets as the extracellular domain of RPTKs can activate RPTKs and enable signal transduction by binding to the corresponding ligands. Herein, we will first introduce the structure and functions of RPTKs. Besides, the progress of the treatment of AXL receptor for liver cancer and human non-small cell lung cancer (NSCLC) and relative medicine development will also be introduced. Furthermore, the mechanism of discoidin domain receptor (DDR) in breast cancer and fibrosis and its medicine development will be included. This assay is not only intended to help people know and understand RPTKs, but also hopes to promote research and developments of related topics.

Citation Download Citation

Mingxin Gu, Yifan Lu, and Yuxin Jin "The profile of receptor protein tyrosine kinases (RPTKs): taking AXL and DDR as examples", Proc. SPIE 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023), 1278911 (7 September 2023); https://doi.org/10.1117/12.2692473

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