A silicon photonics platform based on Mach Zehnder interferometers for real-time bioprocess monitoring

Loic Laplatine; Ali Kheir Aldine; Nicolas Gaignebet; Maryse Fournier; Sonia Messaoudene; Jade Gorry; Malika Amdaoud; Guillaume Nonglaton; Aurélien Lepoetre; Charlotte Parent; Nicolas Sarrut-Rio; Frederic Revol-Cavalier; Stanislas Lhomme

doi:10.1117/12.3001513

12 March 2024 A silicon photonics platform based on Mach Zehnder interferometers for real-time bioprocess monitoring

Loic Laplatine, Ali Kheir Aldine, Nicolas Gaignebet, Maryse Fournier, Sonia Messaoudene, Jade Gorry, Malika Amdaoud, Guillaume Nonglaton, Aurélien Lepoetre, Charlotte Parent, Nicolas Sarrut-Rio, Frederic Revol-Cavalier, Stanislas Lhomme

Author Affiliations +

Proceedings Volume 12835, Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXIV; 128350H (2024) https://doi.org/10.1117/12.3001513
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Bioproduction is becoming increasingly important for the pharmaceutical industry. Real-time impurities monitoring during the purification phase could increase productivity and reduce drug cost. Here, we present a silicon photonics platform based on biofunctionalized Mach Zehnder Interferometers for this application. We demonstrate host cell proteins detection in the μg/ml range within 1 min, as well as the possibility to serially monitor up to 8 samples using a single silicon die.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Loic Laplatine, Ali Kheir Aldine, Nicolas Gaignebet, Maryse Fournier, Sonia Messaoudene, Jade Gorry, Malika Amdaoud, Guillaume Nonglaton, Aurélien Lepoetre, Charlotte Parent, Nicolas Sarrut-Rio, Frederic Revol-Cavalier, and Stanislas Lhomme "A silicon photonics platform based on Mach Zehnder interferometers for real-time bioprocess monitoring", Proc. SPIE 12835, Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXIV, 128350H (12 March 2024); https://doi.org/10.1117/12.3001513

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