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13 March 2024 Noninvasive nanoimaging-nanomanipulation of CRISPR-Cas in cells
Di Zu, Borui Li, Somin Eunice Lee
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Proceedings Volume 12860, Plasmonics in Biology and Medicine XXI; 1286006 (2024) https://doi.org/10.1117/12.3005864
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
CRISPR-Cas9 is significantly potential and versatile gene-editing treatment for neurodegenerative disorders. The CRISPR-Cas9 system incorporates a single guide RNA (sgRNA) and Cas9 nuclease, which helps system to bind to the target sequence, and makes a double-strand break respectively. Viral vectors, as traditional delivery system of CRISPRCas9, cause safety issue regrading immunogenic complications. In this work we present alternative non-viral vectors with plasmonic properties as a delivery system. Our work provides a new perspective of nanoparticles for delivery and visualization applications of the CRISPR-Cas9 system.
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Di Zu, Borui Li, and Somin Eunice Lee "Noninvasive nanoimaging-nanomanipulation of CRISPR-Cas in cells", Proc. SPIE 12860, Plasmonics in Biology and Medicine XXI, 1286006 (13 March 2024); https://doi.org/10.1117/12.3005864
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KEYWORDS
Optical tweezers
Alzheimer disease
Integrated optics
Nanoimaging
Proteins
Visualization
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