Plasmon-based nanowire endoscopy toward a novel platform for intracellular delivery

Tomoko Inose

doi:10.1117/12.3029079

4 October 2024 Plasmon-based nanowire endoscopy toward a novel platform for intracellular delivery

Tomoko Inose

Proceedings Volume 13117, Enhanced Spectroscopies and Nanoimaging 2024; 131170L (2024) https://doi.org/10.1117/12.3029079
Event: Nanoscience + Engineering, 2024, San Diego, California, United States

Abstract

Intracellular delivery of biologically active molecules is an essential tool in modern biotechnology for both fundamental research and therapeutic applications. One of the primary approaches to current intracellular delivery is carrier-based methods, and nanotechnology has greatly contributed to achieving practical carrier-based intracellular delivery. Nanoparticles have emerged as particularly promising vehicles for intracellular delivery. Another mainstream delivery system involves membrane disruption methods using physical techniques such as electrical, mechanical, and thermal stimulation. Micro- and nanoneedles are among the promising tools in membrane disruption methods. In our presentation, we introduce novel approaches for intracellular delivery using a plasmon-based nano-needle. We demonstrate intracellular nitric oxide (NO) gas delivery by coating photosensitive NO release metal-organic framework (NOF-1) on the surface of a plasmonic metal nanowire, achieving time-controlled NO release. Due to the plasmon waveguide phenomenon occurring on the surface of a metal nanowire, we successfully demonstrate remotely controlled NO release from our NOF-1 coated nanowire.

Conference Presentation

Citation Download Citation

Tomoko Inose "Plasmon-based nanowire endoscopy toward a novel platform for intracellular delivery", Proc. SPIE 13117, Enhanced Spectroscopies and Nanoimaging 2024, 131170L (4 October 2024); https://doi.org/10.1117/12.3029079

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