A nano-biocomposite film with ultrahigh photoconductivity remains elusive and critical for bio-optoelectronic applications. A uniform, well-connected, high-concentration nanomaterial network in the biological matrix remains challenging to achieve high photoconductivity. Wafer-scale continuous nano-biocomposite film without surface deformations and cracks play another major obstacle. Here we observed ultrahigh photoconductivity in DNA-MoS2 nano-biocomposite film by incorporating a high-concentration, well-percolated, and uniform MoS2 network in the ss-DNA matrix. This was achieved by utilizing DNA-MoS2 hydrogel formation, which resulted in crack-free, wafer-scale DNA-MoS2 nano-biocomposite films. Ultra-high photocurrent (5.5 mA at 1 V) with a record-high on/off ratio (1.3×10^6) was observed, five orders of magnitude higher than conventional biomaterials (~10^1) reported so far. The incorporation of the Wely semimetal (Bismuth) as an electrical contact exhibited ultrahigh photoresponsivity (2.6×10^5 A/W). Such high photoconductivity in DNA-MoS2 nano-biocomposite could be applicable in biology, electronics, and optics for innovative biomedicine, bioengineering, and neuroscience.
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