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30 September 2024 Biomimetic and immune-compatible designs of mixed-conducting polymers for tissue-interfaced biosensing
Sihong Wang
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Proceedings Volume 13124, Organic and Hybrid Sensors and Bioelectronics XVII; 131240H (2024) https://doi.org/10.1117/12.3028440
Event: Organic Photonics + Electronics, 2024, San Diego, California, United States
Abstract
The use of bioelectronic devices for acquiring biological information and delivering therapeutic interventions relies on direct contact with soft bio-tissues. To ensure high-quality signal transductions, the interfaces between bioelectronic devices and bio-tissues must combine signal amplification with stable and conformable contact. Organic electrochemical transistors based on mixed-conducting polymers have been developed as one of the most advanced technologies for high-performance bio-sensing. However, the rigid mechanical properties and the lack of tissue/skin adhesion from mixed-conducting polymers largely prevent the formation of such intimate and long-term stable bio-interfaces. Also, immune-mediated foreign-body response (FBR) stands as the most widely existing challenge, which can lead to the growth of fibrotic tissue at the tissue-device interface. In this talk, I will first introduce our material and device designs for introducing stretchable and tissue-adhesive properties onto mixed-conducting polymers and OECT-based biosensors. Then, to combat FBR, I will introduce a set of molecular design strategies for enhancing the immune compatibility of mixed-conducting polymers.
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Sihong Wang "Biomimetic and immune-compatible designs of mixed-conducting polymers for tissue-interfaced biosensing", Proc. SPIE 13124, Organic and Hybrid Sensors and Bioelectronics XVII, 131240H (30 September 2024); https://doi.org/10.1117/12.3028440
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KEYWORDS
Polymers
Biosensing
Biomimetics
Materials properties
Interfaces
Adhesion
Biosensors
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