Simultaneous elastography and angiography using optical coherence tomography

Yilin Liang; Xiaochen Meng; Chongyang Wang; Jiang Zhu

doi:10.1117/12.3036198

20 November 2024 Simultaneous elastography and angiography using optical coherence tomography

Yilin Liang, Xiaochen Meng, Chongyang Wang, Jiang Zhu

Author Affiliations +

Proceedings Volume 13242, Optics in Health Care and Biomedical Optics XIV; 1324221 (2024) https://doi.org/10.1117/12.3036198
Event: SPIE/COS Photonics Asia, 2024, Nantong, Jiangsu, China

Conference Poster

Abstract

Optical coherence tomography (OCT) is a non-invasive, label-free imaging modality that generates high-resolution threedimensional images. Based on OCT imaging, optical coherence tomography angiography (OCTA) and optical coherence elastography (OCE) can visualize vascular networks and measure the elastic properties of biological tissues. In previous studies, OCTA and OCE were performed separately, providing either vascular network information or elasticity properties of the tissue. We have developed a simultaneous angiography and elastography method using a simplified sample arm structure. After mechanical pressure is loaded on the sample by a glass plate, the deformation is analyzed by the OCT phase changes, and the elasticity is assessed. Meanwhile, the vascular network is visualized by intensity-based Doppler variance analysis. A transparent flexible reference layer is placed between the glass plate and the tissue, which closely contacts the tissue. Better elasticity measurements can be achieved without affecting vascular imaging. The simultaneous elastography and angiography method was demonstrated by the phantom experiments and rat skin measurements. The results show that the information on the microvascular networks and mechanical properties can be obtained at the same imaging location. The method can provide more comprehensive information on biological tissue for disease diagnosis and treatment monitoring.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Yilin Liang, Xiaochen Meng, Chongyang Wang, and Jiang Zhu "Simultaneous elastography and angiography using optical coherence tomography", Proc. SPIE 13242, Optics in Health Care and Biomedical Optics XIV, 1324221 (20 November 2024); https://doi.org/10.1117/12.3036198

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE