TCGA database-based determination of prognostic genes associate with immunity in TSCC

Mengling Zhang; Jin Yang; Yuhan Jiang; Yanhui Li; Meihua Bao

doi:10.1117/12.3044280

27 August 2024 TCGA database-based determination of prognostic genes associate with immunity in TSCC

Mengling Zhang, Jin Yang, Yuhan Jiang, Yanhui Li, Meihua Bao

Author Affiliations +

Proceedings Volume 13252, Fourth International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2024); 132521B (2024) https://doi.org/10.1117/12.3044280
Event: 2024 Fourth International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2024), 2024, Kaifeng, China

Abstract

Tongue squamous cell carcinoma (TSCC) is an oral cancer affecting the epithelial cells of the tongue. It is a serious and potentially lethal disease that requires prompt diagnosis and treatment. Multiple genes associated with immunity have been discovered as crucial in the growth and progression of cancer. In this research, we analyzed the gene expression profiles of patients with TSCC from TCGA database. A prognostic model for TSCC was established using five immune-related genes: TRAP1, LAT, NPY, IL20, and LBP. The prognostic model demonstrated its effectiveness, reliability, and stability through Kaplan-Meier, ROC curve, and both univariate and multivariate analysis. This immune-based prognostic model offers a biomarker for monitoring long-term treatment outcomes in TSCC but also suggests a potential immunotherapy approach for this disease.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Mengling Zhang, Jin Yang, Yuhan Jiang, Yanhui Li, and Meihua Bao "TCGA database-based determination of prognostic genes associate with immunity in TSCC", Proc. SPIE 13252, Fourth International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2024), 132521B (27 August 2024); https://doi.org/10.1117/12.3044280

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