Reusable meta surface biosensors based on Fano resonance with microfluidic technology

Wei Wei; Xiaoqing Lv; Chengcheng Huang; Huan Zhang; Pengying Chang; Yiyang Xie

doi:10.1117/12.3033517

16 October 2024 Reusable meta surface biosensors based on Fano resonance with microfluidic technology

Wei Wei, Xiaoqing Lv, Chengcheng Huang, Huan Zhang, Pengying Chang, Yiyang Xie

Author Affiliations +

Proceedings Volume 13291, Ninth International Symposium on Advances in Electrical, Electronics, and Computer Engineering (ISAEECE 2024); 1329106 (2024) https://doi.org/10.1117/12.3033517
Event: Ninth International Symposium on Advances in Electrical, Electronics, and Computer Engineering (ISAEECE 2024), 2024, Changchun, China

Abstract

Gold metarsurfaces are widely used in sensing due to their ability to enhance localized light fields. To reduce the manufacturing cost of gold metasurfaces, we proposed a reusable metasurface biosensor based on parylene C with microfluidic technology. The electric field distribution of the gold metasurface was simulated using the finite-difference time-domain (FDTD) method. The polydimethylsiloxane (PDMS) microfluidic channels were bounded on the surface of the biosensor to provide specific reaction area to detect different concentrations of NaCl solution. For the purpose of reusability, the growth and removal of parylene C on the metasurface were realized. Besides, the parylene C film acted as the connection layer to enable the one-step physical modification of antigen and antibody, which made highly efficient biosensing possible. The feasibility of this approach is experimentally validated and has potential to be widely used in other metasurface biosensors.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Wei Wei, Xiaoqing Lv, Chengcheng Huang, Huan Zhang, Pengying Chang, and Yiyang Xie "Reusable meta surface biosensors based on Fano resonance with microfluidic technology", Proc. SPIE 13291, Ninth International Symposium on Advances in Electrical, Electronics, and Computer Engineering (ISAEECE 2024), 1329106 (16 October 2024); https://doi.org/10.1117/12.3033517

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KEYWORDS

Biosensors

Microfluidics

Metals

Refractive index

Gold

Electric fields

Surface plasmons

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