Correlation of results obtained by in-vivo optical spectroscopy with measured blood oxygen saturation using a positive linear regression fit

Patrick W. McCormick; Gary D. Lewis; Manuel Dujovny M.D.; James I. Ausman M.D.; Mick Stewart; Ronald A. Widman

doi:10.1117/12.59361

6 May 1992 Correlation of results obtained by in-vivo optical spectroscopy with measured blood oxygen saturation using a positive linear regression fit

Patrick W. McCormick, Gary D. Lewis, Manuel Dujovny M.D., James I. Ausman M.D., Mick Stewart, Ronald A. Widman

Author Affiliations +

Proceedings Volume 1641, Physiological Monitoring and Early Detection Diagnostic Methods; (1992) https://doi.org/10.1117/12.59361
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

Near infrared light generated by specialized instrumentation was passed through artificially oxygenated human blood during simultaneous sampling by a co-oximeter. Characteristic absorption spectra were analyzed to calculate the ratio of oxygenated to reduced hemoglobin. A positive linear regression fit between diffuse transmission oximetry and measured blood oxygenation over the range 23% to 99% (r² equals .98, p < .001) was noted. The same technology was used to pass two channels of light through the scalp of brain-injured patients with prolonged, decreased level of consciousness in a tertiary care neuroscience ICU. Transmission data were collected with gross superficial-to-deep spatial resolution. Saturation calculation based on the deep signal was observed in the patient over time. The procedure was able to be performed clinically without difficulty; rSO₂ values recorded continuously demonstrate the usefulness of the technique. Using the same instrumentation, arterial input and cerebral response functions, generated by IV tracer bolus, were deconvoluted to measure mean cerebral transit time. Date collected over time provided a sensitive index of changes in cerebral blood flow as a result of therapeutic maneuvers.

Citation Download Citation

Patrick W. McCormick, Gary D. Lewis, Manuel Dujovny M.D., James I. Ausman M.D., Mick Stewart, and Ronald A. Widman "Correlation of results obtained by in-vivo optical spectroscopy with measured blood oxygen saturation using a positive linear regression fit", Proc. SPIE 1641, Physiological Monitoring and Early Detection Diagnostic Methods, (6 May 1992); https://doi.org/10.1117/12.59361

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available