Meso-tetra (4-carboxyphenyl) porphyrin--fluorescence behavior, photodynamic treatment, and tissue distribution

Wolfgang S. L. Strauss; Werner Mohr; Karsten Koenig; Kurt Miller; Angelika C. Rueck; Herbert Schneckenburger; Rudolf W. Steiner

doi:10.1117/12.168699

1 March 1994 Meso-tetra (4-carboxyphenyl) porphyrin--fluorescence behavior, photodynamic treatment, and tissue distribution

Wolfgang S. L. Strauss, Werner Mohr, Karsten Koenig, Kurt Miller, Angelika C. Rueck, Herbert Schneckenburger, Rudolf W. Steiner

Author Affiliations +

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168699
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

Athymic nude mice with subcutaneously xenotransplanted urothelial carcinoma received intravenously injections of the synthetic sensitizer meso-tetra (4-carboxyphenyl) porphyrin. Fluorescence at the tumors and the skin was excited using a Kr⁺ laser (407 nm) and was detected at 652 nm using a fiberoptical sensor in combination with an optical multichannel analyzer at different times after application of the sensitizer. Photodynamic treatment was carried out using an Ar⁺ laser pumped dye laser (650 nm; 100 mW/cm²; 100 J/cm²). The delay of tumor growth was determined in a follow-up period of four weeks and was correlated to the in vivo fluorescence measurements.

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Wolfgang S. L. Strauss, Werner Mohr, Karsten Koenig, Kurt Miller, Angelika C. Rueck, Herbert Schneckenburger, and Rudolf W. Steiner "Meso-tetra (4-carboxyphenyl) porphyrin--fluorescence behavior, photodynamic treatment, and tissue distribution", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168699

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