Effects of oxidative stress on erythrocyte deformability and fragility

Serdar Caglayan; Rainer Bayer

doi:10.1117/12.167463

1 February 1994 Effects of oxidative stress on erythrocyte deformability and fragility

Serdar Caglayan, Rainer Bayer

Proceedings Volume 2082, Quantification and Localization Using Diffuse Photons in a Highly Scattering Medium; (1994) https://doi.org/10.1117/12.167463
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

Most methods established so far to estimate RBC deformability are hard to standardize and include high error of measurement. For our present investigation on the effects of oxygen (O₂) and ozone (O₃) on red blood cell (RBC) deformability we used the method of laser diffraction in a combination of image analysis. After exposing RBC to O₂ and/or O₃ mechanical fragility was investigated by filtration of the RBC suspensions (hematocrit 5%) through 3 micrometers pore filter under pressure of 200 mmHg. Fragility remained unchanged after oxygenation. Astonishingly O₃ in concentration >= 7 (mu) g/ml improved mechanical fragility (decrease of hemolysis after mechanical stress).

Citation Download Citation

Serdar Caglayan and Rainer Bayer "Effects of oxidative stress on erythrocyte deformability and fragility", Proc. SPIE 2082, Quantification and Localization Using Diffuse Photons in a Highly Scattering Medium, (1 February 1994); https://doi.org/10.1117/12.167463

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