About nonlinearity of dependence of dose-effect in photodamage of biological membranes

Vladimir Bolodon; Eugene A. Chernitsky

doi:10.1117/12.197491

2 January 1995 About nonlinearity of dependence of dose-effect in photodamage of biological membranes

Vladimir Bolodon, Eugene A. Chernitsky

Proceedings Volume 2370, 5th International Conference on Laser Applications in Life Sciences; (1995) https://doi.org/10.1117/12.197491
Event: Laser Applications in Life Sciences: 5th International Conference, 1994, Minsk, Belarus

Abstract

Dose dependences of the photolysis rate of erythrocytes and total fraction of leukocytes sensitized by hematoporphyrin have been investigated. It is shown that power index of the dose dependence is equal approximately to 2.2 and 1.4 for erythrocytes and leukocytes respectively, when cell photolysis occurred in a medium with neutral pH. This index for erythrocytes lysed in alkaline medium is equal approximately to 1.3. It is shown that the reason for such modification of the power index of photohemolysis dose dependence is not changing of photochemical processes but it consists in alteration of some light independent processes connected with pH-induced modification of membrane structure. It is suggested that such changing of membrane structure is related to the band 3 protein of erythrocyte membranes.

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Vladimir Bolodon and Eugene A. Chernitsky "About nonlinearity of dependence of dose-effect in photodamage of biological membranes", Proc. SPIE 2370, 5th International Conference on Laser Applications in Life Sciences, (2 January 1995); https://doi.org/10.1117/12.197491

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