Comparative study of laser action on normal atherosclerotically damaged vessel tissue: dynamical and photochemical aspects

Eugeni P. Gordov; Michail M. Makogon; Sergey V. Mel'chenko; Vladimir M. Shipulin M.D.; Iren V. Sukhodolo; E. D. Alekseeva; Nataliya S. Hegay; A. F. Terpugova; I. S. Tyryshkin

doi:10.1117/12.230361

19 January 1996 Comparative study of laser action on normal atherosclerotically damaged vessel tissue: dynamical and photochemical aspects

Eugeni P. Gordov, Michail M. Makogon, Sergey V. Mel'chenko, Vladimir M. Shipulin M.D., Iren V. Sukhodolo, E. D. Alekseeva, Nataliya S. Hegay, A. F. Terpugova, I. S. Tyryshkin

Author Affiliations +

Proceedings Volume 2623, Medical Applications of Lasers III; (1996) https://doi.org/10.1117/12.230361
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

A set of laboratory experiments was performed to study a possibility of selective laser action on different classes of atherosclerotic plaques and samples of normal vessel walls were performed. To this end Nd:YAG-laser with frequency doubler and quadrupler as well as XeCl-laser with SRS cell were employed which allows us to compare results of laser action in broad spectral range. The laboratory setups permit us to vary parameters of laser radiation, such as the pulse duration, energy and density of the energy in process of experiments. All samples were subjected to detailed morphological study. Experiments performed indicate the possibility of initiation of photochemical destruction of plaques by UV laser radiation. Such a possibility is supported also by semi-empiric quantum chemistry calculations performed for fat acids. All this allows us to suggest a sort of optimal strategy for laser destruction of atherosclerotic plaques with minimal site effects.

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Eugeni P. Gordov, Michail M. Makogon, Sergey V. Mel'chenko, Vladimir M. Shipulin M.D., Iren V. Sukhodolo, E. D. Alekseeva, Nataliya S. Hegay, A. F. Terpugova, and I. S. Tyryshkin "Comparative study of laser action on normal atherosclerotically damaged vessel tissue: dynamical and photochemical aspects", Proc. SPIE 2623, Medical Applications of Lasers III, (19 January 1996); https://doi.org/10.1117/12.230361

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KEYWORDS

Ultraviolet radiation

Laser tissue interaction

Visible radiation

Pulsed laser operation

Excimer lasers

Absorption

Chemistry

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