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From a cw-laser beam transmitted to strongly scattering tissue most photons have been scattered and therefore a complicated unknown path in tissue and decoding of the optical tissue parameter from the intensity of the scattered photons is very difficult. But some of the transmitted photons could undergo the absorption and scattering. From its intensity the integral sum of the absorption and scattering coefficient can be calculated easily for its well known straight way. With a focused laser beam by scanning the sample in x, y and z-direction the optical parameters can be calculated with high lateral resolution. To distinguish between scattered and non-scattered photons, a Mach-Zehnder interferometer can be employed.
Klaus Doerschel,Olaf Minet, andGerhard J. Mueller
"High-resolution coherent tomography", Proc. SPIE 2732, CIS Selected Papers: Coherence-Domain Methods in Biomedical Optics, (9 February 1996); https://doi.org/10.1117/12.231690
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Klaus Doerschel, Olaf Minet, Gerhard J. Mueller, "High-resolution coherent tomography," Proc. SPIE 2732, CIS Selected Papers: Coherence-Domain Methods in Biomedical Optics, (9 February 1996); https://doi.org/10.1117/12.231690