Low-coherence imaging of cerebral structures in vivo

David H. Reitze; Steven Roper; M. D. Moores; Grigory V. Gelikonov; Felix I. Feldchtein; N. M. Beach; Natalia D. Gladkova; Valentin M. Gelikonov; Alexander M. Sergeev; Ludmila Snopova

doi:10.1117/12.274302

22 May 1997 Low-coherence imaging of cerebral structures in vivo

David H. Reitze, Steven Roper, M. D. Moores, Grigory V. Gelikonov, Felix I. Feldchtein, N. M. Beach, Natalia D. Gladkova, Valentin M. Gelikonov, Alexander M. Sergeev, Ludmila Snopova

Author Affiliations +

Proceedings Volume 2981, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications; (1997) https://doi.org/10.1117/12.274302
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

We present the results of detailed optical coherence tomographic (OCT) observations of both normal and abnormal rat neocortices obtained in vivo. A compact fast-scanning OCT device employing simultaneously two superluminescent sources of radiation at different wavelengths (0.83 and 1.28 micron) has recorded three dimensional images and performed two-color comparative analysis of the tomograms. We are able to obtain image information at 2.5 mm depths, enabling imaging through the entire rat cerebral cortex. Structures inside and at the surface of the brain have been optically detected, including the dura matter, blood vessels, and the hippocampal/cortical boundary. From these, we have recorded and stored the first OCT album of the cortex. Subsequent histologic analysis shows a good correlation with the OCT tomograms, particularly within the cortical surface layers and the boundary between gray and white matter. We are also able to detect differences between normal and abnormal cerebral structure using OCT.

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David H. Reitze, Steven Roper, M. D. Moores, Grigory V. Gelikonov, Felix I. Feldchtein, N. M. Beach, Natalia D. Gladkova, Valentin M. Gelikonov, Alexander M. Sergeev, and Ludmila Snopova "Low-coherence imaging of cerebral structures in vivo", Proc. SPIE 2981, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications, (22 May 1997); https://doi.org/10.1117/12.274302

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KEYWORDS

Optical coherence tomography

Brain

Cerebrum

Skull

In vivo imaging

Tissues

Blood vessels

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