Infusion technique allowing long-term tumor targeting with antibodies on the hen's egg test (HET) system

Anja Vervoorts; Tatyana A. Karmakova; Irene Rose; Joerg G. Moser

doi:10.1117/12.297799

29 December 1997 Infusion technique allowing long-term tumor targeting with antibodies on the hen's egg test (HET) system

Anja Vervoorts, Tatyana A. Karmakova, Irene Rose, Joerg G. Moser

Author Affiliations +

Proceedings Volume 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III; (1997) https://doi.org/10.1117/12.297799
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

The accumulation of antibodies or their fragments in tumor tissues is a basal requirement for immunotargeting of tumors in vivo. Immunotargeting is the first step for a polyphasic tumor therapy and diagnosis. Usually the high interstitial pressure and the insufficient blood supply of the tumor prevents the accumulation of tumor specific antibodies. To overcome these barriers the antibodies can be modified concerning their molecular weight. On the other hand, different injection techniques can influence the antibody distribution in-vivo. We developed a long term infusion technique for the testing of antibodies and antibody fragments in xenotransplanted tumors in the hen's egg test system. This in-vivo model allows to develop new protocols for the antibody administration resulting in a tumor localization without targeting of non-tumor tissues. Macroscopic and microscopic findings in the HET-system may reflect the binding sites of antibodies in-situ. Detection of tumor markers has not yet been realized due to problems inherent to the system.

Citation Download Citation

Anja Vervoorts, Tatyana A. Karmakova, Irene Rose, and Joerg G. Moser "Infusion technique allowing long-term tumor targeting with antibodies on the hen's egg test (HET) system", Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); https://doi.org/10.1117/12.297799

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