Investigations to monitor laser-induced thermotherapy (LITT) of breast tumors with photon density waves (PDW)

I. Mesecke-von Rheinbaben; Andre Roggan; Y. Helfman; Uwe Netz; G. Mueller

doi:10.1117/12.350037

14 June 1999 Investigations to monitor laser-induced thermotherapy (LITT) of breast tumors with photon density waves (PDW)

I. Mesecke-von Rheinbaben, Andre Roggan, Y. Helfman, Uwe Netz, G. Mueller

Author Affiliations +

Proceedings Volume 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical; (1999) https://doi.org/10.1117/12.350037
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

An experimental setup will be presented which provides the detection of photon density waves (PDW) in transmission through tissue samples of up to 4 cm thickness. A laser diode (825 nm) which was modulated at frequencies between 40 - 1000 MHz served as light source. Amplitude and phase of the PDW were measured at various positions on tissue phantoms as well as during interstitial laser coagulation of tissue samples (porcine liver) by scanning source and detector. A Nd:YAG laser was used in combination with a scattering applicator to produce thermal lesions. Due to a change of the optical properties the actual size of the coagulated volume could be monitored during the therapy. Several phantom and in vitro experiments have been performed to show that this monitoring technique is capable of visualizing the coagulated region with a clinically relevant precision.

Citation Download Citation

I. Mesecke-von Rheinbaben, Andre Roggan, Y. Helfman, Uwe Netz, and G. Mueller "Investigations to monitor laser-induced thermotherapy (LITT) of breast tumors with photon density waves (PDW)", Proc. SPIE 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical, (14 June 1999); https://doi.org/10.1117/12.350037

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available