Photodynamic processes of cholesteryl oleate accumulated on the arterial wall using IR free electron lasers

Kunio Awazu; Katsuo Aizawa

doi:10.1117/12.349993

14 June 1999 Photodynamic processes of cholesteryl oleate accumulated on the arterial wall using IR free electron lasers

Kunio Awazu, Katsuo Aizawa

Author Affiliations +

Proceedings Volume 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical; (1999) https://doi.org/10.1117/12.349993
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

The selective removal of cholesterol esters accumulated in the intra-cellular or extra-cellular spaces has clinical significance. In the present work we investigate the removal of cholesterol esters by using a free electron laser (FEL) in an arteriosclerotic region. Thin films of cholesteryl oleate and albumin, and the cross section of a rabbit artery were placed on an inverted microscope stage and the changes caused by the FEL irradiation of 5.75 micrometer and 6.1 micrometer with 1.5 - 3 mW in average were monitored continuously by a CCD camera in real time. FEL irradiation at a wavelength of 5.75 micrometer, which is a stretching vibrational mode of the ester, was able to ablate cholesterol esters without affecting albumin and that it can also remove cholesterol esters from rabbits' arteriosclerotic arterial walls.

Citation Download Citation

Kunio Awazu and Katsuo Aizawa "Photodynamic processes of cholesteryl oleate accumulated on the arterial wall using IR free electron lasers", Proc. SPIE 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical, (14 June 1999); https://doi.org/10.1117/12.349993

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