Biomedical applications of the information-efficient spectral imaging sensor (ISIS)

Stephen M. Gentry; Richard M. Levenson

doi:10.1117/12.346734

21 April 1999 Biomedical applications of the information-efficient spectral imaging sensor (ISIS)

Proceedings Volume 3603, Systems and Technologies for Clinical Diagnostics and Drug Discovery II; (1999) https://doi.org/10.1117/12.346734
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

The ISIS approach to spectral imaging seeks to bridge the gap between tuned multispectral and fixed hyperspectral imaging sensor. By allowing the definition of completely general spectral filter functions, truly optimal measurement can be made for a given task. These optimal measurements significantly improve signal to noise ratio and speed, minimize data volume and data rate, while preserving classification accuracy. This paper investigates the application of the ISIS sensing approach in two sample biomedical applications: prostate and colon cancer screening. It is shown that is these applications, two to three optimal measurements are sufficient to capture the majority of classification information for critical samples constituents. In the prostate cancer example, the optimal measurements allow 8 percent relative improvement in classification accuracy of critical cell constituents over a red, green, blue (RGB) sensor. In the colon cancer example, use of optimal measurements boost the classification accuracy of critical cell constituents by 28 percent relative to the RGB sensor. In both cases, optimal measurements match the performance achieved by the entire hyperspectral data set. The paper concludes that an ISIS style spectral imager can acquire these optimal spectral images directly, allowing improved classification accuracy imager can acquire these optimal spectral images directly, allowing improved classification accuracy over an RGB sensor. Compared to a hyperspectral sensor, the ISIS approach can achieve similar classification accuracy using a significantly lower number of spectral samples, thus minimizing overall sample classification time and cost.

Citation Download Citation

Stephen M. Gentry and Richard M. Levenson "Biomedical applications of the information-efficient spectral imaging sensor (ISIS)", Proc. SPIE 3603, Systems and Technologies for Clinical Diagnostics and Drug Discovery II, (21 April 1999); https://doi.org/10.1117/12.346734

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