Spatiotemporal activity patterns detected from single cell measurements from behaving animals

Alessandro E. P. Villa; Igor V. Tetko

doi:10.1117/12.343039

22 March 1999 Spatiotemporal activity patterns detected from single cell measurements from behaving animals

Alessandro E. P. Villa, Igor V. Tetko

Proceedings Volume 3728, Ninth Workshop on Virtual Intelligence/Dynamic Neural Networks; (1999) https://doi.org/10.1117/12.343039
Event: Ninth Workshop on Virtual Intelligence/Dynamic Neural Networks: Neural Networks Fuzzy Systems, Evolutionary Systems and Virtual Re, 1998, Stockholm, Sweden

Abstract

Precise temporal patterning of activity within and between neurons has been predicted on theoretical grounds, and found in the spike trains of neurons recorded from anesthetized and conscious animals, in association with sensor stimuli and particular phases of task performance. However, the functional significance of such patterning in the generation of behavior has not been confirmed. We recorded from multiple single neurons in regions of rat auditory cortex during the waiting period of a Go/NoGo task. During this time the animal waited for an auditory signal with high cognitive load. Of note is the fact that neural activity during the period analyzed was essentially stationary, with no event related variability in firing. Detected patterns therefore provide a measure of brain state that could not be addressed by standard methods relying on analysis of changes in mean discharge rate. The possibility is discussed that some patterns might reflect a preset bias to a particular response, formed in the waiting period. Others patterns might reflect a state of prior preparation of appropriate neural assemblies for analyzing a signal that is expected but of unknown behavioral valence.

Citation Download Citation

Alessandro E. P. Villa and Igor V. Tetko "Spatiotemporal activity patterns detected from single cell measurements from behaving animals", Proc. SPIE 3728, Ninth Workshop on Virtual Intelligence/Dynamic Neural Networks, (22 March 1999); https://doi.org/10.1117/12.343039

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