Anterior ciliary sclerotomy: effect on corneal topography, globe integrity, and the role of a novel antifibrotic gel

Peggy Lamar; Viviana Fernandez; Fabrice Manns; Sander Dubovy; Stanley Zipper; Samith Sandadi; Natsushi Nakagawa; Marc Weiser; Francois Malecaze; Jean-Marie A. Parel

doi:10.1117/12.470603

13 June 2002 Anterior ciliary sclerotomy: effect on corneal topography, globe integrity, and the role of a novel antifibrotic gel

Peggy Lamar, Viviana Fernandez, Fabrice Manns, Sander Dubovy, Stanley Zipper, Samith Sandadi, Natsushi Nakagawa, Marc Weiser, Francois Malecaze, Jean-Marie A. Parel

Author Affiliations +

Proceedings Volume 4611, Ophthalmic Technologies XII; (2002) https://doi.org/10.1117/12.470603
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

To (1) quantify changes in corneal topography induced by radial anterior sclerostomy for restoring accommodation and, (2) assess safety and ant fibrosis activity of cross-linked sodium hyaluronic acid (cSHA) based gels in ACS procedures. Methods (ex-vivo study): 6 fresh human Eye-Bank eyes were used. A 15% Dextran solution was injected in the anterior chamber and the vitreous cavity, the corneal epithelium was removed by scraping, and the whole eye was immersed in 15% Dextran solution until corneal thickness reached a physiological value. The conjunctiva and tenon capsule were removed and the eye was mounted on a custom-made holder. Preoperative corneal topography was measured with a PAR corneal topography system. Five to eight 3mm-long linear equidistant anterior radial incisions starting from the limbus were performed in the sclera at 90% depth with a diamond blade. Postoperative corneal topography was measured. The files providing the pre and postoperative tangential curvature along meridians separated by 5 degrees were exported. The axial curvature along the 0 and 90-degree meridians before and after surgery were compared. Methods (in-vivo study): Of 24 rabbits, 4 were operated following Thornton's (90% depth incision) and 20 following Fukasaku's (100% depth) techniques (total peritomy, four 4mm long radial scleral incisions starting 0.5 mm from the limbus).

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Peggy Lamar, Viviana Fernandez, Fabrice Manns, Sander Dubovy, Stanley Zipper, Samith Sandadi, Natsushi Nakagawa, Marc Weiser, Francois Malecaze, and Jean-Marie A. Parel "Anterior ciliary sclerotomy: effect on corneal topography, globe integrity, and the role of a novel antifibrotic gel", Proc. SPIE 4611, Ophthalmic Technologies XII, (13 June 2002); https://doi.org/10.1117/12.470603

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