Evaluating acute physiological responses of porcine epidermis exposed to a pulsed 3.8-micron laser

Golda C. Winston; Thomas E. Johnson; Donald Q. Randolph; Thomas A. Neal M.D.

doi:10.1117/12.529740

1 July 2004 Evaluating acute physiological responses of porcine epidermis exposed to a pulsed 3.8-μm laser

Golda C. Winston, Thomas E. Johnson, Donald Q. Randolph, Thomas A. Neal M.D.

Proceedings Volume 5319, Laser Interaction with Tissue and Cells XV; (2004) https://doi.org/10.1117/12.529740
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Five male Yorkshire pigs were exposed on their flank to 4 microsecond pulses of laser light from a Deuterium Fluoride 3.8 micron Laser at varying energies. A preliminary ED₅₀ threshold for various skin reactions was determined for this laser exposure combination. The animal’s skin was assessed for injury immediately, 1 hour, 24 hours and 72 hours post exposure. In general, energies below 3.2 J/cm² leave no lasting skin reaction. As energy increased above the threshold, erythema or skin reddening was easily visualized. High-energy pulses appear to produce a “rug burn” erythema without evidence of punctate hemorrage (bleeding) or coagulation. Laser exposure sites on the pigs were also biopsied to obtain histopathological results. These findings suggest that the principal effect of this type of in-vivo laser exposure is removal of the epithelium, while not damaging the papillary dermis or structures beneath the Basement Membrane Zone (BMZ).

Citation Download Citation

Golda C. Winston, Thomas E. Johnson, Donald Q. Randolph, and Thomas A. Neal M.D. "Evaluating acute physiological responses of porcine epidermis exposed to a pulsed 3.8-μm laser", Proc. SPIE 5319, Laser Interaction with Tissue and Cells XV, (1 July 2004); https://doi.org/10.1117/12.529740

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KEYWORDS

Skin

Injuries

Laser safety

Standards development

Laser damage threshold

Pulsed laser operation

Tissues

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