Study on the therapeutic effects of low-energy laser therapy combined with cyclophosphamide on the mouse ascites sarcoma

Hongbin Wang; Baoxu Huang; Huanqi Liu; Zhina Qu; Xifeng Liu; Shaohui Cheng

doi:10.1117/12.572054

29 July 2004 Study on the therapeutic effects of low-energy laser therapy combined with cyclophosphamide on the mouse ascites sarcoma

Hongbin Wang, Baoxu Huang, Huanqi Liu, Zhina Qu, Xifeng Liu, Shaohui Cheng

Author Affiliations +

Proceedings Volume 5486, ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics; (2004) https://doi.org/10.1117/12.572054
Event: ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics, 2003, Silsoe, United Kingdom

Abstract

By using the experimental model of mouse S180 ascites sarcoma, the feasibility and mechanism of low-energy laser therapy combined with the traditional antitumor drug of cyclophosphamide in the treatment of malignant tumors were discussed. The S180 ascites sarcoma suffering BALB/c mice were irradiated upon the Harder's glands with the dosages of 11.00, 14.67 and 22.00 J/cm² respectively, and/or injected with CYT intraperitoneally to evaluate the therapeutic effects of CYT/LELT combination on malignant tumors. The three dosages of LELT combined with CYT all showed remarkably therapeutic effects on the mouse S180 ascites sarcoma. Comparatively, the dosage of 14.67J/cm² LELT combined with CYT showed the most ideal therapeutic effects and the survival time was up to 20.80 days, and the life prolongation ratio was 33.33% which was remarkably higher than those of the CYT and tumor control groups. CYT/LELT combined therapy had remarkably inhibiting effects on the mice ascites growth because of the existence of CYT.

Citation Download Citation

Hongbin Wang, Baoxu Huang, Huanqi Liu, Zhina Qu, Xifeng Liu, and Shaohui Cheng "Study on the therapeutic effects of low-energy laser therapy combined with cyclophosphamide on the mouse ascites sarcoma", Proc. SPIE 5486, ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics, (29 July 2004); https://doi.org/10.1117/12.572054

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