Near-IR radiation has great potential in medical diagnosis and therapy because of the non-invasive nature of light
and the selectively poisonous effect to tumors of photodynarnic treatment. Therefore, Near-IR light propagation in highly
scattering biological tissue must be understudied for basic research and clinical application of biomedical optics. A tissue
is multi-layered mismatched medium, but many investigators only study the diffusion equation of matched medium. they
take the tissue as the same refractive index. In order to understand the light transport in tissue, We analyze the diffusion
of photons three-layered mismatched medium and set up the solution of Green's function in frequency domain, we
employ the extrapolated boundary condition to set up a solution of the diffusion equation. At the same time, we utilize
the diffuse equation to calculate the phase in different situation
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