Treatment of retinal detachment with an encircling band and buckle implant: A comparative pilot study between poly (styrene-b-isobutylene-b-styrene) (SIBS) and trimethyl terminated polydimethylsiloxane (PDMS)

Mariela Aguilar; Hideo Yamamoto; Edgar Espana; Ana Carolina Acosta; Marcia Orozco; Mohamed Aly; Esdras Arrieta; Eleut Hernandez; John Martin; Sander Dubovy; William Smiddy; Leonard Pinchuk; Jean-Marie Parel

doi:10.1117/12.661174

7 March 2006 Treatment of retinal detachment with an encircling band and buckle implant: A comparative pilot study between poly (styrene-b-isobutylene-b-styrene) (SIBS) and trimethyl terminated polydimethylsiloxane (PDMS)

Mariela Aguilar, Hideo Yamamoto, Edgar Espana, Ana Carolina Acosta, Marcia Orozco, Mohamed Aly, Esdras Arrieta, Eleut Hernandez, John Martin, Sander Dubovy, William Smiddy, Leonard Pinchuk, Jean-Marie Parel

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Proceedings Volume 6138, Ophthalmic Technologies XVI; 61381S (2006) https://doi.org/10.1117/12.661174
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Purpose: To demonstrate the biocompatibility of SIBS implants as compared to PDMS implants in the treatment of retinal detachment in New Zealand White (NZW) rabbit model.^1,2 Introduction: Scleral encircling bands, fixation rings and buckles are utilized for closure of retinal breaks and retina reattachment. The FDA approved PDMS-implant is associated with several post-operative complications, involving thick-fibrotic encapsulations. SIBS, an elastomeric triblock copolymer, was recently FDA approved for use in a cardiovascular drug eluting stent (TAXUS^TM, Boston Scientific Corp., MA) and showed excellent biocompatibility and slow drug release capability. Materials and Methods: SIBS (9-mol%-styrene) implants were fabricated (InnFocus LLC, USA) to match PDMS implants (Labtician, Inc, Canada) dimensions. 5 NZW rabbits received SIBS and 4, PDMS-implants. Post-operative exam sequence: day 1 and 2, week 1, 2, 3, 4 and 6, and monthly thereafter for up to 1 year. Anatomohistopathology exams sequence: one SIBS animal at 6 weeks and one animal of each treatment group at 3 and 6-months, and two at 12-months. Results: SIBS compared to PDMS animals exhibited less inflammation and a better buckling effect during the first 6 weeks. At POD 9 months, the conjunctival injection in the SIBS rabbit was none as opposed to the PDMS value and the buckling effect for both groups were equal. There were no visible signs of encapsulation with SIBS. There were no infections in the 9 animals and none of the implants extruded thus far (<10 months). Conclusion: SIBS encircling bands, sleeves, and buckle implants are well tolerated in the rabbit model.

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Mariela Aguilar, Hideo Yamamoto, Edgar Espana, Ana Carolina Acosta, Marcia Orozco, Mohamed Aly, Esdras Arrieta, Eleut Hernandez, John Martin, Sander Dubovy, William Smiddy, Leonard Pinchuk, and Jean-Marie Parel "Treatment of retinal detachment with an encircling band and buckle implant: A comparative pilot study between poly (styrene-b-isobutylene-b-styrene) (SIBS) and trimethyl terminated polydimethylsiloxane (PDMS)", Proc. SPIE 6138, Ophthalmic Technologies XVI, 61381S (7 March 2006); https://doi.org/10.1117/12.661174

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KEYWORDS

Wound healing

Inflammation

Surgery

Retina

Eye

Animal model studies

Medicine

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