Alexey N. Bashkatov,1 Alexander N. Korolevich,2,3 Mikhail M. Stolnitz,1 Elina A. Genina,1 Valery V. Tuchinhttps://orcid.org/0000-0001-7479-2694,1 Yuri P. Sinichkin,1 Nataly S. Dubina,4 Sergey I. Vecherinski,4 Michael S. Belsley2
1Saratov State Univ. (Russia) 2Minho Univ. (Portugal) 3B.I. Stepanov Institute of Physics (Belarus) 4GP MTZ Medservice (Belarus)
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We present experimental results on optical properties of the human skin controlled by administration ofthe 40%-glucose
solution. In vivo reflectance spectra of the human skin were measured. Results of the experimental study of influence of
the 40%-glucose solution on reflectance spectra of the human skin are presented. A significant decrease of reflectance of
the human skin under action of the osmotic agent is demonstrated. The experiments show that administration of the
glucose solution allows for effective control of tissue optical characteristics, that makes skin more transparent, thereby
increasing the ability of light penetration through the tissue. Laser Doppler flowmetry has been used for study of skin
blood microcirculation under the action of the glucose solution. Results of the experiments demonstrated that at the
action of the glucose solution blood perfusion and blood concentration increase, however the mean blood velocity does
not change. The presented results can be used in developing functional imaging techniques, including OCT and
reflectance spectroscopy. A potential benefit of the optical clearing technique is the improvement of laser therapeutic
techniques that rely on sufficient light penetration to a target embedded in tissue.
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Alexey N. Bashkatov, Alexander N. Korolevich, Mikhail M. Stolnitz, Elina A. Genina, Valery V. Tuchin, Yuri P. Sinichkin, Nataly S. Dubina, Sergey I. Vecherinski, Michael S. Belsley, "Optical clearing of skin tissue produced by application of glucose solution: in vivo study," Proc. SPIE 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII, 616313 (21 July 2006); https://doi.org/10.1117/12.697313