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Neurovascular coupling in the optic nerve is the physiological mechanism that adjusts the blood perfusion in the
microcirculation of the optic nerve to support the neural activity induced by vision. The resulting variations in blood
flow and thus in neural tissue oxygenation induce changes in the optical properties of the tissues. These variations can
be detected optically as reflectivity changes in the neural tissues, i.e. the retina and optic nerve disk. To achieve a better
understanding of the mechanisms underlying the neurovascular coupling, our study is aimed at the evaluation of
reflectance changes of the optic nerve induced by visual stimulation. For this purpose, an ocular fundus reflectometer
has been developed.
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Matteo Bonaiuti, Luigi Rovati, Charles E. Riva, "A system for functional imaging of the ocular fundus," Proc. SPIE 6426, Ophthalmic Technologies XVII, 642612 (5 March 2007); https://doi.org/10.1117/12.700786