Nonlinear diffusivity of analytes in tissues

Mohamad G. Ghosn; Esteban F. Carbajal; Natasha A. Befrui; Valery V. Tuchin; Kirill V. Larin

doi:10.1117/12.762166

5 February 2008 Nonlinear diffusivity of analytes in tissues

Mohamad G. Ghosn, Esteban F. Carbajal, Natasha A. Befrui, Valery V. Tuchin, Kirill V. Larin

Proceedings Volume 6855, Complex Dynamics and Fluctuations in Biomedical Photonics V; 685503 (2008) https://doi.org/10.1117/12.762166
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Noninvasive assessments of optical clearing and permeability coefficients of tissues pose great possibilities in advanced diagnostics and medical applications. In order for both of these to become utilized in common practice, a greater understanding of molecular diffusivity in multi-layered tissues is required. In biological tissues, the different layers are comprised of differentiated cells and/or collagen fibrils which come together to form that specific layer. Therefore, a patchwork of layers is created each with its own set of properties. In our current study we analyze and describe the dynamics of matter diffusion and its underlying non-linear character in various epithelial tissues. For instance, the permeability coefficient (PC) of 20% concentrated mannitol in the rabbit eye sclera showed an increasing trend as it was measured deeper into the tissue. The PC was found to be 2.18 × 10^-6 cm/sec at 50 μm away from the epithelial layer. It increased to about 7.33 × 10^-6 cm/sec when it was computed at 210 μm from the epithelial layer. Different layers in the sclera showed different clearing response to glucose solution as well. The first 100 μm region from the epithelial layer cleared about 10% whereas the next 100 μm cleared about 17-22%. The importance of this study is that it may offer a novel explanation to how a layer's composition affects optical clearing and the permeability coefficient of analytes and solutions.

Citation Download Citation

Mohamad G. Ghosn, Esteban F. Carbajal, Natasha A. Befrui, Valery V. Tuchin, and Kirill V. Larin "Nonlinear diffusivity of analytes in tissues", Proc. SPIE 6855, Complex Dynamics and Fluctuations in Biomedical Photonics V, 685503 (5 February 2008); https://doi.org/10.1117/12.762166

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available