Wide field visualization of retinal and choroidal microstructure in vivo using frequency domain OCT at 1060 nm with up to 47000 lines/s

Boris Hermann; M. Esmaeelpour; Boris Povazay; Bernd Hofer; F. Bounaparte; Nick Sheen; Rachel North; Wolfgang Drexler

doi:10.1117/12.809253

23 February 2009 Wide field visualization of retinal and choroidal microstructure in vivo using frequency domain OCT at 1060 nm with up to 47000 lines/s

Boris Hermann, M. Esmaeelpour, Boris Povazay, Bernd Hofer, F. Bounaparte, Nick Sheen, Rachel North, Wolfgang Drexler

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Proceedings Volume 7163, Ophthalmic Technologies XIX; 71630A (2009) https://doi.org/10.1117/12.809253
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

We present in vivo frequency domain optical coherence tomography of the human retina and choroid in the 1060 nm water transmission window with 72 nm optical bandwidth (<8 &mgr;m axial resolution in tissue) and up to 74 frames per second (`a 512 x 512 pixels). A novel InGaAs stripe array with 1024 pixels and 47000 lines/s read out rate is utilized in combination with an all reflective spectrometer to enable densely sampled wide field scans (35°x°35), i.e. ~10x10 mm²) acquired in less than 7 seconds. At this speed numerical motion artifact removal algorithms are sufficient to compensate remaining involuntary drifts of the subject's eye. Enhanced penetration beyond the retina enables for the first time highly isotropically sampled, three-dimensional visualization of all three layers of the choroidal vasculature without the need of contrast agents, the choroidal-scleral interface as well as the first scleral layer, the absorbing lamina fusca sclerae. Furthermore the choroidal thickness was quantified in 30 healthy subjects and correlated with axial eye length. First results indicate an decrease in choroidal thickness with increasing axial eye length.

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Boris Hermann, M. Esmaeelpour, Boris Povazay, Bernd Hofer, F. Bounaparte, Nick Sheen, Rachel North, and Wolfgang Drexler "Wide field visualization of retinal and choroidal microstructure in vivo using frequency domain OCT at 1060 nm with up to 47000 lines/s", Proc. SPIE 7163, Ophthalmic Technologies XIX, 71630A (23 February 2009); https://doi.org/10.1117/12.809253

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KEYWORDS

Optical coherence tomography

Eye

Visualization

Retina

Absorption

In vivo imaging

Indium gallium arsenide

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