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30 December 2008 Comparative study on functionalized SBA-15 and SBA-16 nanostructured materials used for immobilization of D-amino acid oxidase
Le Gia Hy, Dang Tuyet Phuong, Hoang Yen, Nguyen Thi Vuong Hoan, Bui Thi Hai Linh, Hoang Vinh Thang, Tran Thi Kim Hoa, Dinh Cao Thang, Vu Thi Hanh Nguyen, Phan Thi Hong Thao, Chu Van Giap, Vu Anh Tuan
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Proceedings Volume 7270, Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems; 727017 (2008) https://doi.org/10.1117/12.810706
Event: SPIE Smart Materials, Nano- and Micro-Smart Systems, 2008, Melbourne, Australia
Abstract
SBA-15 and SBA-16 nanostucrured materials were synthesized via hydrothermal treatment and were functionalized with 3-aminopropyltriethoxysilane (APTES), and vinyltriethoxysilane (VTES). The obtained samples were characterized by different techniques such as XRD, BET, IR and TEM. After functionalization, it showed that these nanostrucrured materials were still maintained the hexagonal pore structure of the parent SBA-15 and cubic cage structure of the parent SBA-16. The non-functionalized pure silica SBA-15 and SBA-16 as well as functionalized SBA-15 and SBA-16 materials were used to immobilize DAAO, which is industrially important enzyme for the production of glutaryl 7-amino cephalosporanic acid (GL-7-ACA) from cephalosporin C (CPC). The obtained results revealed that functionalized SBA- 15 and SBA-16 materials exhibited higher enzymatic activity and stability than those of non-functionalized ones. This might be due to the enhancing of surface hydrophobicity upon functionalization. The surface functionalization of the nanostructured silicas with organic groups can enhance the interaction between enzyme and the supports and consequently increasing the operational stability of the immobilized enzyme. The loading of enzyme on SBA-15 materials was higher than that on SBA-16 samples (both functionalized and non-functionalized types). This might be explained by the difference in pore size and type (cylindrical for SBA-15 and bottle-neck for SBA-16) as well as structure shape (hexagonal for SBA-15 and cubic cage for SBA-16) of both mesoporous materials. Additionally, nature of functionalized groups significantly affected the enzymatic activity. Effects on surface binding force, nature of functional groups, pore size of supports were investigated and discussed.
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Le Gia Hy, Dang Tuyet Phuong, Hoang Yen, Nguyen Thi Vuong Hoan, Bui Thi Hai Linh, Hoang Vinh Thang, Tran Thi Kim Hoa, Dinh Cao Thang, Vu Thi Hanh Nguyen, Phan Thi Hong Thao, Chu Van Giap, and Vu Anh Tuan "Comparative study on functionalized SBA-15 and SBA-16 nanostructured materials used for immobilization of D-amino acid oxidase", Proc. SPIE 7270, Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems, 727017 (30 December 2008); https://doi.org/10.1117/12.810706
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KEYWORDS
Silica
Nanostructuring
Solids
Transmission electron microscopy
Compound parabolic concentrators
Natural surfaces
Adsorption
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