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A surface plasmon resonance (SPR) sensor to quantify glucose using a molecularly imprinted polymer was developed.
The polymer was prepared by crosslinking poly(allylamine) in the presence of glucose phosphate, monobarium salt
(GPS-Ba) and attached to a thin film of gold (50 nm) which had been sputtered on top of a glass slide, via amide
coupling. Upon removal of the template, this sensor was used to detect glucose in human urine in physiologically
significant levels (1-20 mg/ml). Signal enhancement of the glucose sensor was made possible by incorporating gold
nanoparticles in the polymer.
Soame Banerji,Wei Peng,Yoon-Chang Kim, andKarl S. Booksh
"Chemically responsive hydrogel with nanoparticle enhanced detection for small biomolecules", Proc. SPIE 7674, Smart Biomedical and Physiological Sensor Technologies VII, 76740A (23 April 2010); https://doi.org/10.1117/12.854610
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Soame Banerji, Wei Peng, Yoon-Chang Kim, Karl S. Booksh, "Chemically responsive hydrogel with nanoparticle enhanced detection for small biomolecules," Proc. SPIE 7674, Smart Biomedical and Physiological Sensor Technologies VII, 76740A (23 April 2010); https://doi.org/10.1117/12.854610