Lab-on-a-chip sensor for measuring Zn by stripping voltammetry

Xing Pei; Wenjing Kang; Wei Yue; Adam Bange; Hector R. Wong; William R. Heineman; Ian Papautsky

doi:10.1117/12.910621

14 February 2012 Lab-on-a-chip sensor for measuring Zn by stripping voltammetry

Xing Pei, Wenjing Kang, Wei Yue, Adam Bange, Hector R. Wong, William R. Heineman, Ian Papautsky

Proceedings Volume 8251, Microfluidics, BioMEMS, and Medical Microsystems X; 82510K (2012) https://doi.org/10.1117/12.910621
Event: SPIE MOEMS-MEMS, 2012, San Francisco, California, United States

Abstract

This work reports on continuing development of a lab-on-a-chip sensor for electrochemical detection of heavy metal zinc in blood serum. The sensor consists of a three electrode system, including an environmentally-friendly bismuth working electrode, a Ag/AgCl reference electrode, and a gold auxiliary electrode. By optimizing the electrodeposition of bismuth film, better control of fabrication steps and improving interface between the sensor and potentiostat, repeatability and sensitivity of the lab-on-a-chip sensor has been improved. Through optimization of electrolyte and stripping voltammetry parameters, limits of detection were greatly improved. The optimized sensor was able to measure zinc in in the physiological range of 65-95 μg/dL. Ultimately, with further development and integrated sample preparation sensor system will permit rapid (min) measurements of zinc from a sub-mL sample (a few drops of blood) for bedside monitoring.

Citation Download Citation

Xing Pei, Wenjing Kang, Wei Yue, Adam Bange, Hector R. Wong, William R. Heineman, and Ian Papautsky "Lab-on-a-chip sensor for measuring Zn by stripping voltammetry", Proc. SPIE 8251, Microfluidics, BioMEMS, and Medical Microsystems X, 82510K (14 February 2012); https://doi.org/10.1117/12.910621

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