Application of optical coherence tomography for assessment of transcutaneous vaccine delivery

T. Kamali; T. Rattanapak; S. Hook; I. Meglinski

doi:10.1117/12.923733

28 February 2012 Application of optical coherence tomography for assessment of transcutaneous vaccine delivery

T. Kamali, T. Rattanapak, S. Hook, I. Meglinski

Proceedings Volume 8337, Saratov Fall Meeting 2011: Optical Technologies in Biophysics and Medicine XIII; 833706 (2012) https://doi.org/10.1117/12.923733
Event: Saratov Fall Meeting 2011, 2011, Saratov, Russian Federation

Abstract

Immunization is one of the most efficient and cost-effective means for the prevention of diseases, but most vaccines have to be administered invasively. A novel strategy of inducing an immune response is topical application of vaccines to intact skin. Apart from being a non-invasive route of drug delivery, skin delivery also offers an advantageous mode of immunization due to the ability of skin immune cells to present antigens to the immune system. Topical vaccine penetration through the outermost layers of skin is based on the percutaneous diffusion of lipid-based nano-particles. In the current study we investigate the applicability of Optical Coherence Tomography for monitoring transcutaneous delivery of a peptide vaccine into the skin in vivo.

Citation Download Citation

T. Kamali, T. Rattanapak, S. Hook, and I. Meglinski "Application of optical coherence tomography for assessment of transcutaneous vaccine delivery", Proc. SPIE 8337, Saratov Fall Meeting 2011: Optical Technologies in Biophysics and Medicine XIII, 833706 (28 February 2012); https://doi.org/10.1117/12.923733

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
5 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Skin

Optical coherence tomography

In vivo imaging

Imaging systems

Diffusion

Water

Tissues

Show All Keywords

Keywords/Phrases

Search In:

Publication Years