B. P. Cunkelman,1 E. Y. Chen,2,3 A. A. Petryk,1 J. A. Tate,1 S. G. Thappa,3 R. J. Collier,1 P. J. Hoopes1,2,3
1Thayer School of Engineering at Dartmouth (United States) 2Geisel School of Medicine (United States) 3Dartmouth-Hitchcock Medical Ctr. (United States)
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Treatments of the post-operative surgical bed have proven appealing as the majority of cancer recurrence following
tumor resection occurs at the tumor margin. A novel, biodegradable pullulan-based gel infused with magnetic iron oxide
nanoparticles (IONP) is presented here for surgical bed administration followed by hyperthermia therapy via alternating
magnetic field (AMF) activation. Pullulan is a water soluble, film-forming starch polymer that degrades at the postoperative
wound site to deliver the IONP payload, targeting the remaining cancer cells. Different gel formulations
containing various % wt of pullulan were tested for IONP elution. Elution levels and amount of gel degradation were
measured by immersing the gel in de-ionized water for one hour then measuring particle concentrations in the
supernatant and the mass of the remaining gel formulation. The most promising gel formulations will be tested in a
murine model of surgical bed resection to assess in vivo gel dissolution, IONP cell uptake kinetics via histology and
TEM analysis, and heating capability of the gel with AMF exposure.
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B. P. Cunkelman, E. Y. Chen, A. A. Petryk, J. A. Tate, S. G. Thappa, R. J. Collier, P. J. Hoopes, "Development of a biodegradable iron oxide nanoparticle gel for tumor bed therapy," Proc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VII, 858411 (26 February 2013); https://doi.org/10.1117/12.2007310