Novel algorithm for background correction of the quantitative spectroscopic tomography of the biogenic-substances

Pradeep K. W. Abeygunawardhana; Wei Qi; Daisuke Kojima; Satoru Suzuki; Akira Nishiyama; Ichirou Ishimaru

doi:10.1117/12.2003402

25 February 2013 Novel algorithm for background correction of the quantitative spectroscopic tomography of the biogenic-substances

Pradeep K. W. Abeygunawardhana, Wei Qi, Daisuke Kojima, Satoru Suzuki, Akira Nishiyama, Ichirou Ishimaru

Author Affiliations +

Proceedings Volume 8591, Optical Diagnostics and Sensing XIII: Toward Point-of-Care Diagnostics; 85910O (2013) https://doi.org/10.1117/12.2003402
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

The non-invasive blood sugar sensor by using imaging-type 2-dimensional Fourier spectroscopy is to be realized in this work. The spectroscopic imaging, that observes the biological tissue by the dark-field image, can measure the biogenic substance quantitatively such as the glucose concentration. For the quantitative analysis with high accuracy, the correction of the background such as the light-source fluctuation and the phase-shift uncertainty is inevitable issue. Thus, the quantitative band-pass plate on which the grating is locally formed has been already proposed by [1]. In that paper, the diffractive light, whose diffraction angle depends on the wavelength, has been used as the reference light. Object lens is used to narrow down the reference light and narrowed band pass diffraction light is obtained. The changes of imaging intensities with interference phenomenon on whole area of the observation image can be confirmed using the quantitative band pass filter. This paper proposed background correction method of the interferogram in spectroscopic tomography. Correction algorithm mainly contained two parts as light source fluctuation error correction and phase shift error correction.

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Pradeep K. W. Abeygunawardhana, Wei Qi, Daisuke Kojima, Satoru Suzuki, Akira Nishiyama, and Ichirou Ishimaru "Novel algorithm for background correction of the quantitative spectroscopic tomography of the biogenic-substances", Proc. SPIE 8591, Optical Diagnostics and Sensing XIII: Toward Point-of-Care Diagnostics, 85910O (25 February 2013); https://doi.org/10.1117/12.2003402

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