Joint reconstruction of activity and attenuation map using LM SPECT emission data

Abhinav K. Jha; Eric Clarkson; Matthew A. Kupinski; Harrison H. Barrett

doi:10.1117/12.2008111

19 March 2013 Joint reconstruction of activity and attenuation map using LM SPECT emission data

Abhinav K. Jha, Eric Clarkson, Matthew A. Kupinski, Harrison H. Barrett

Author Affiliations +

Proceedings Volume 8668, Medical Imaging 2013: Physics of Medical Imaging; 86681W (2013) https://doi.org/10.1117/12.2008111
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

Attenuation and scatter correction in single photon emission computed tomography (SPECT) imaging often requires a computed tomography (CT) scan to compute the attenuation map of the patient. This results in increased radiation dose for the patient, and also has other disadvantages such as increased costs and hardware complexity. Attenuation in SPECT is a direct consequence of Compton scattering, and therefore, if the scattered photon data can give information about the attenuation map, then the CT scan may not be required. In this paper, we investigate the possibility of joint reconstruction of the activity and attenuation map using list- mode (LM) SPECT emission data, including the scattered-photon data. We propose a path-based formalism to process scattered-photon data. Following this, we derive analytic expressions to compute the Cram´er-Rao bound (CRB) of the activity and attenuation map estimates, using which, we can explore the fundamental limit of information-retrieval capacity from LM SPECT emission data. We then suggest a maximum-likelihood (ML) scheme that uses the LM emission data to jointly reconstruct the activity and attenuation map. We also propose an expectation-maximization (EM) algorithm to compute the ML solution.

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Abhinav K. Jha, Eric Clarkson, Matthew A. Kupinski, and Harrison H. Barrett "Joint reconstruction of activity and attenuation map using LM SPECT emission data", Proc. SPIE 8668, Medical Imaging 2013: Physics of Medical Imaging, 86681W (19 March 2013); https://doi.org/10.1117/12.2008111

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