Tryptophan content for monitoring breast cancer cell aggressiveness by native fluorescence spectroscopy

Lin Zhang; Yang Pu; Jianpeng Xue; Sebastião Pratavieira; Baogang Xu; Samuel Achilefu; R. R. Alfano

doi:10.1117/12.2038712

17 March 2014 Tryptophan content for monitoring breast cancer cell aggressiveness by native fluorescence spectroscopy

Lin Zhang, Yang Pu, Jianpeng Xue, Sebastião Pratavieira, Baogang Xu, Samuel Achilefu, R. R. Alfano

Proceedings Volume 8940, Optical Biopsy XII; 894015 (2014) https://doi.org/10.1117/12.2038712
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

This study shows tryptophan as the key native marker in cells to determine the level of aggressive cancer in breast cell lines using native fluorescence spectroscopy. An algorithm based on the ratio of tryptophan fluorescence intensity at 340 nm to intensity at 460 nm is associated with aggressiveness of the cancer cells. The higher the ratio is, the more aggressive the tumor towards metastasis.

Citation Download Citation

Lin Zhang, Yang Pu, Jianpeng Xue, Sebastião Pratavieira, Baogang Xu, Samuel Achilefu, and R. R. Alfano "Tryptophan content for monitoring breast cancer cell aggressiveness by native fluorescence spectroscopy", Proc. SPIE 8940, Optical Biopsy XII, 894015 (17 March 2014); https://doi.org/10.1117/12.2038712

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
9 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Cancer

Breast cancer

Luminescence

Particle filters

Breast

Fluorescence spectroscopy

Tissues

Show All Keywords

Keywords/Phrases

Search In:

Publication Years